Wydarzenia
Seminarium- prof. Takashi Hayashita
Data dodania: 16-10-2018 | Autor: Anna Chwał
Szanowni Państwo,
W dn. 23 października 2018 r. (wtorek) o godz. 13.00 w sali A-139 odbędzie się seminarium, w trakcie którego prof. Takashi Hayashita z Sophia University (Tokyo, Japan) przedstawi wykład pt.: "Design and Function of Novel Supramolecular Complex Sensors Based on Cyclodextrin Complexes and Self-assembling Systems”
Serdecznie zapraszamy Państwa do udziału w seminarium.
STRESZCZENIE WYSTĄPIENIA
The selective transduction of molecular recognition events into physical or chemical signals is a key concept for the design of novel supramolecular sensors. Cyclodextrins (CyDs) are attractive hosts for construction of supramolecular structures since water-soluble CyDs possess nanosize hydrophobic cavities which behave as a “molecular flask” to incorporate various guest molecules in water. Similarly nanoparticle sensors are promising because their surfaces and chemical structures are easily controlled and various types of recognition sites can be introduced on the surface of nanoparticles1). In this study, the supramolecular functions of CyD complexes and the self-assembling systems based on nanoparticles were used for the design of supramolecular complex sensors for ion and molecule recognition in water. Using various combinations of CyDs with fluorescent probes and azoprobes possessing phenylboronic acid or dipycolylamine (dpa) binding sites, a highly selective guest recognition was achieved in water by means of CyD complexes1), chemically modified CyD complexes2), and CyD gel complexes1) based on their synergistic functions. We have shown that the 2:1 inclusion complex of ditopic azoprobes with γ-CD realized a novel supramolecular chirality in response with multi-point binding of guest ions3). For the other type of supramolecular complex sensors, we have designed amphiphilic phenylboronic acid azoprobes. Guest-induced changes in aggregate structures were successfully used for saccharide recognition4). Similarly, anionic phenylboronic acid probes were self-assembled on the surface of various generations of polyamidoamine dendrimers for specific saccharide recognition in water. The fluorescent nanoparticles having depa-metal complexes or phenylboronic acids on their surface were found to form selective aggregation with vacteria, which were easily observed by the naked eye5). These novel supramolecular functions are discussed in relation with their supramolecular complex structures in water (Fig. 1) 1). This work was financially supported by a Grant-in-Aid for Scientific Research (A) (Grant No. 26248038) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.